Cyclooxygenase-2 inhibition in colon experimental carcinogenesis
نویسندگان
چکیده
منابع مشابه
Inhibition of cyclooxygenase-2 in experimental severe acute pancreatitis.
BACKGROUND The standard treatment for acute pancreatitis (AP) is still based on supportive care. The search for a new drug that could change the natural history of the disease is a continuing challenge for many researchers. The aim of this study is to evaluate the effect of a cyclooxygenase-2 (COX-2) inhibitor on experimental AP in rats. METHODS The animals were divided into 2 groups: Group 1...
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Cyclooxygenases (COX) also known as prostaglandin (PG) synthases are found in two forms, COX-1 and COX-2. While COX-1 is responsible for cytoprotective functions in a number of organs, COX-2, which is normally absent at basal levels, is induced under certain conditions. Induction of COX-2 is found in many pathophysiological states including acute inflammation, arthritis, as well as in cancer an...
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Epidemiological and laboratory studies indicate an inverse relationship between the risk of colon cancer development and intake of nonsteroidal antiinflammatory agents, including aspirin. One of the mechanisms by which nonsteroidal antiinflammatory agents inhibit colon carcinogenesis is through the inhibition of prostaglandin production by cyclooxygenase isozymes (COX-1 and COX-2). Overexpressi...
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Epidemlological and laboratory studies indicate an inverse relationship between the risk of colon cancer development and intake of nonsteroldal antiinflammatory agents, including aspirin. One of the mechanisms by which nonsteroidal antiinflammatory agents Inhibit colon carcInogenesis Is through the inhibition of prostaglandIn production by cyclooxygenase isozymes (COX-1 and COX-2). Overexpressi...
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Scientific literature shows that inflammation and oxidative stress contribute in the pathogenesis of atherosclerosis. The oxidative stress is the consequence of an imbalance between the free radical generation and elimination. One source of free oxygen radicals is cyclooxygenase (COX)-2 and, therefore, inhibiting the activity of this enzyme is likely to reduce oxidative stress. In the present s...
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ژورنال
عنوان ژورنال: Revista Española de Enfermedades Digestivas
سال: 2005
ISSN: 1130-0108
DOI: 10.4321/s1130-01082005000900004